کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3421836 1226689 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Is selection relevant in the evolutionary emergence of drug resistance?
ترجمه فارسی عنوان
آیا انتخاب در رابطه با ظهور تکاملی مقاومت دارویی مرتبط است؟
کلمات کلیدی
نجات تکاملی، شیمی درمانی، آنتی بیوتیک ها، پنجره انتخاب جهش یافته
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروب شناسی
چکیده انگلیسی


• We argue that the strength of selection can be a poor predictor of the emergence of drug resistance.
• Drug resistance can emerge when selected against and can fail to emerge when under positive selection.
• We suggest that the absolute fitness of drug-resistant strains is a more relevant predictor of emergence.
• We argue that the within-host ecology, and how this is affected by drug pressure, is a primary determinant of absolute fitness.
• We demonstrate how within-host ecology can be tied to the familiar MSW hypothesis.

The emergence of drug-resistant pathogens is often considered a canonical case of evolution by natural selection. Here we argue that the strength of selection can be a poor predictor of the rate of resistance emergence. It is possible for a resistant strain to be under negative selection and still emerge in an infection or spread in a population. Measuring the right parameters is a necessary first step toward the development of evidence-based resistance-management strategies. We argue that it is the absolute fitness of the resistant strains that matters most and that a primary determinant of the absolute fitness of a resistant strain is the ecological context in which it finds itself.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 23, Issue 3, March 2015, Pages 126–133
نویسندگان
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