کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3421970 1226703 2013 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Lose the battle to win the war: bacterial strategies for evading host inflammasome activation
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروب شناسی
پیش نمایش صفحه اول مقاله
Lose the battle to win the war: bacterial strategies for evading host inflammasome activation
چکیده انگلیسی


• Inflammasomes are multiprotein complexes that mediate the activation of caspase-1.
• Inflammasome activation is triggered by infection by many pathogens.
• Pathogens possess several strategies for evading inflammasome activation.

The inflammasome is composed of nucleotide-binding, oligomerization domain (NOD)-like receptor (NLR) proteins, and leads to caspase-1 activation and subsequent secretion of the proinflammatory cytokines interleukin 1β (IL-1β) and interleukin-18 (IL-18). After certain pathogenic bacteria infect host cells, such as macrophages, NLR-mediated inflammasome activation is triggered to form part of the host defenses against the invading pathogens. However, recent evidence has shown that bacteria have strategies for evading inflammasome activation in host cells. In this review, we focus on NLR-mediated inflammasome activation and bacterial evasion of the inflammasome as part of the battle between the host defenses and pathogens.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 21, Issue 7, July 2013, Pages 342–349
نویسندگان
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