کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3423095 | 1226988 | 2012 | 13 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: The tumorigenic liver fluke Opisthorchis viverrini – multiple pathways to cancer The tumorigenic liver fluke Opisthorchis viverrini – multiple pathways to cancer](/preview/png/3423095.png)
Liver fluke infection caused by Opisthorchis viverrini is a major public health problem in Thailand and adjacent countries. In addition to infection-associated morbidity, infection with O. viverrini and the related Clonorchis sinensis are unarguable risk factors for cholangiocarcinoma (CAA, bile-duct cancer). Here we review the pathogenesis of opisthorchiasis and the association between O. viverrini infection and bile-duct cancer, focusing on the molecular parallels between wound healing, chronic inflammation, and cancer development. We review a schema for human disease progression from fluke infection, chronic opisthorchiasis, advanced periductal fibrosis, and cholangiocarcinogenesis, and present a rationale for biomarker discovery to facilitate early intervention. We conclude by addressing post-genomic advances with a view to developing new control strategies to combat this infectious cancer.
Journal: - Volume 28, Issue 10, October 2012, Pages 395–407