کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3423095 1226988 2012 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The tumorigenic liver fluke Opisthorchis viverrini – multiple pathways to cancer
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی انگل شناسی
پیش نمایش صفحه اول مقاله
The tumorigenic liver fluke Opisthorchis viverrini – multiple pathways to cancer
چکیده انگلیسی

Liver fluke infection caused by Opisthorchis viverrini is a major public health problem in Thailand and adjacent countries. In addition to infection-associated morbidity, infection with O. viverrini and the related Clonorchis sinensis are unarguable risk factors for cholangiocarcinoma (CAA, bile-duct cancer). Here we review the pathogenesis of opisthorchiasis and the association between O. viverrini infection and bile-duct cancer, focusing on the molecular parallels between wound healing, chronic inflammation, and cancer development. We review a schema for human disease progression from fluke infection, chronic opisthorchiasis, advanced periductal fibrosis, and cholangiocarcinogenesis, and present a rationale for biomarker discovery to facilitate early intervention. We conclude by addressing post-genomic advances with a view to developing new control strategies to combat this infectious cancer.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 28, Issue 10, October 2012, Pages 395–407
نویسندگان
, , , , , , , ,