کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3423177 1226998 2013 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
New insights into the machinery of blood digestion by ticks
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی انگل شناسی
پیش نمایش صفحه اول مقاله
New insights into the machinery of blood digestion by ticks
چکیده انگلیسی


• Ticks digest blood intracellularly by a multi-enzyme system of cysteine and aspartic proteases.
• A similar proteolytic machinery is employed by evolutionarily distant hematophagous parasites.
• Tick digestive system offers new targeted strategies to control ticks and tick-borne diseases.

Blood-protein digestion is a key physiological process providing essential nutrients for ticks and is a prerequisite for the transmission of tick-borne pathogens. Recently, substantial progress has been made in determining the proteolytic machinery in tick gut tissue, which is based on a dynamic multienzyme network capable of processing a vast amount of host blood. In this article we summarize our current knowledge of the molecular mechanisms of tick hematophagy and their similarities to those of Platyhelminthes, nematodes, and Plasmodium. Future research perspectives, including the potential for rational control of ticks and transmitted diseases, are also discussed.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 29, Issue 6, June 2013, Pages 276–285
نویسندگان
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