کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3423237 | 1227008 | 2012 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Host targeting of virulence determinants and phosphoinositides in blood stage malaria parasites
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
انگل شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Host targeting of virulence determinants and phosphoinositides in blood stage malaria parasites Host targeting of virulence determinants and phosphoinositides in blood stage malaria parasites](/preview/png/3423237.png)
چکیده انگلیسی
Blood stage malaria parasites target a ‘secretome’ of hundreds of proteins including virulence determinants containing a host (cell) targeting (HT) signal, to human erythrocytes. Recent studies reveal that the export mechanism is due to the HT signal binding to the lipid phosphatidylinositol-3-phosphate [PI(3)P] in the parasite endoplasmic reticulum (ER). An aspartic protease plasmepsin V which cleaves a specialized form of the HT signal was previously thought to be the export mechanism, but is now recognized as a dedicated peptidase that cleaves the signal anchor subsequent to PI(3)P binding. We discuss a model of PI(3)P-dependent targeting and PI(3)P biology of a major human pathogen.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 28, Issue 12, December 2012, Pages 555–562
Journal: - Volume 28, Issue 12, December 2012, Pages 555–562
نویسندگان
Souvik Bhattacharjee, Robert V. Stahelin, Kasturi Haldar,