کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3424799 1227247 2011 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Inhibition of the epidermal growth factor receptor by erlotinib prevents immortalization of human cervical cells by Human Papillomavirus type 16
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ویروس شناسی
پیش نمایش صفحه اول مقاله
Inhibition of the epidermal growth factor receptor by erlotinib prevents immortalization of human cervical cells by Human Papillomavirus type 16
چکیده انگلیسی

The Human Papillomavirus type-16 (HPV-16) E6 and E7 oncogenes are selectively retained and expressed in cervical carcinomas, and expression of E6 and E7 is sufficient to immortalize human cervical epithelial cells. Expression of the epidermal growth factor receptor (EGFR) is often increased in cervical dysplasia and carcinoma, and HPV oncoproteins stimulate cell growth via the EGFR pathway. We found that erlotinib, a specific inhibitor of EGFR tyrosine kinase activity, prevented immortalization of cultured human cervical epithelial cells by the complete HPV-16 genome or the E6/E7 oncogenes. Erlotinib stimulated apoptosis in cells that expressed HPV-16 E6/E7 proteins and induced senescence in a subpopulation of cells that did not undergo apoptosis. Since immortalization by HPV E6/E7 is an important early event in cervical carcinogenesis, the EGFR is a potential target for chemoprevention or therapy in women who have a high risk for cervical cancer.


► We examined the effect on EGF-R inhibition in HPV-infected cervical cells.
► Erlotinib prevented immortalization of cells by HPV-16.
► Erlotinib stimulated apoptosis in cells that expressed HPV-16.
► Erlotinib induced senescence in cells that did not undergo apoptosis.
► The EGF-R may be a potential target for chemoprevention

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Virology - Volume 421, Issue 1, 5 December 2011, Pages 19–27
نویسندگان
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