کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3425389 1227281 2010 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Coxsackievirus B5 induced apoptosis of HeLa cells: Effects on p53 and SUMO
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ویروس شناسی
پیش نمایش صفحه اول مقاله
Coxsackievirus B5 induced apoptosis of HeLa cells: Effects on p53 and SUMO
چکیده انگلیسی

Coxsackievirus B5 (CVB5), a human enterovirus of the family Picornaviridae, is a frequent cause of acute and chronic human diseases. The pathogenesis of enteroviral infections is not completely understood, and the fate of the CVB5-infected cell has a pivotal role in this process. We have investigated the CVB5-induced apoptosis of HeLa cells and found that it happens by the intrinsic pathway by a mechanism dependent on the ubiquitin–proteasome system, associated with nuclear aggregation of p53. Striking redistribution of both SUMO and UBC9 was noted at 4 h post-infection, simultaneously with a reduction in the levels of the ubiquitin-ligase HDM2. Taken together, these results suggest that CVB5 infection of HeLa cells elicit the intrinsic pathway of apoptosis by MDM2 degradation and p53 activation, destabilizing protein sumoylation, by a mechanism that is dependent on a functional ubiquitin–proteasome system.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Virology - Volume 396, Issue 2, 20 January 2010, Pages 256–263
نویسندگان
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