کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3425856 | 1227302 | 2008 | 8 صفحه PDF | دانلود رایگان |
Although defensins are known to inhibit the replication of human influenza A virus (IAV) in vitro, their in vivo expression during IAV infection is not known. Here we investigated mRNA and protein expression of several β-defensins in the airways of IAV infected mice. Expression of murine β-defensin (MBD)-3 and -4 was enhanced (3 to 5-fold, p < 0.01) in infected lungs, trachea and sinonasal mucosa. MBD-3 and -4 expressions were correlated with the time course of acute IAV infection suggesting their induction by IAV infection. Infected mice also showed increased levels of surfactant protein-D especially in the sinonasal mucosa. MBD-3 and -4 were localized to the conducting airway epithelial cells but not the alveolar tissue. We conclude that IAV infection upregulated the expression of inducible β-defensins in both the upper and lower airways. These novel findings suggest that β-defensins might contribute to innate and adaptive immune responses targeted against IAV infection.
Journal: Virology - Volume 380, Issue 1, 10 October 2008, Pages 136–143