کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3426090 1227315 2007 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Heparan sulfate is a binding molecule but not a receptor for CEACAM1-independent infection of murine coronavirus
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ویروس شناسی
پیش نمایش صفحه اول مقاله
Heparan sulfate is a binding molecule but not a receptor for CEACAM1-independent infection of murine coronavirus
چکیده انگلیسی

A highly neurovirulent mouse hepatitis virus (MHV) JHMV strain (wt) with receptor (MHVR)-independent infection activity and its low-virulent mutant srr7 without such activity were found to attach to MHVR-negative, non-permissive BHK cells. To identify the molecule that interacts with JHMV, we focused on heparan sulfate (HS) since it works as a receptor of a mutant MHV-rec1 that infects in an MHVR-independent fashion. The present study indicates that HS interacts with both wt JHMV and srr7 but it does not function as an entry receptor as it apparently does for MHV-rec1. Furthermore, HS failed to serve as an entry receptor in the MHVR-independent infection of wt JHMV, indicating that HS is not a host factor that wt JHMV utilizes in an MHVR-independent infection.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Virology - Volume 366, Issue 1, 15 September 2007, Pages 16–22
نویسندگان
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