کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3426726 1227342 2007 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
High level of genetic heterogeneity in S and P genes of genotype D hepatitis B virus
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ویروس شناسی
پیش نمایش صفحه اول مقاله
High level of genetic heterogeneity in S and P genes of genotype D hepatitis B virus
چکیده انگلیسی

The genetic heterogeneity of hepatitis B virus (HBV) genotypes and subgenotypes was investigated by directly sequencing amplified PreS, S and P genes of HBV isolates obtained from the plasma of 99 subjects with chronic HBV infection. Genotype D showed the greatest intragenotypic and intrasubgenotypic divergence: in particular, the a determinant was mutated in 58.2% of the genotype D patients, two of whom showed prototypic vaccine-induced escape mutants at codon 145. Moreover, five sites under significant positive selection were found in the S protein of the D isolates: one in the a determinant and four in the highly hydrophobic C terminal.Our results suggest that careful surveillance of vaccine-induced escape mutants should be considered in populations with highly frequent genotype D infections, and raise questions concerning the possible relationship between the genetic heterogeneity, host immunity and pathogenicity of this HBV genotype.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Virology - Volume 365, Issue 1, 15 August 2007, Pages 113–124
نویسندگان
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