کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3426891 1227349 2007 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Enhancement of gene transactivation activity of androgen receptor by hepatitis B virus X protein
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ویروس شناسی
پیش نمایش صفحه اول مقاله
Enhancement of gene transactivation activity of androgen receptor by hepatitis B virus X protein
چکیده انگلیسی

Hepatitis B virus (HBV) X protein (HBx) is a regulatory protein that is required for efficient replication of HBV in its natural host. In this report, we demonstrate by co-immunoprecipitation experiments that HBx can physically bind to the androgen receptor (AR), which is a nuclear hormone receptor that is expressed in many different tissues including the liver. This observation is further supported by confocal microscopy, which reveals that HBx can alter the subcellular localization of the AR both in the presence and in the absence of dihydrotestosterone (DHT). Further studies indicate that HBx can enhance the gene transactivation activity of AR by enhancing its DNA binding activity in a DHT-dependent manner. However, HBx does not remain associated with AR on the DNA. As AR can regulate the expression of a number of cellular genes, our results raise the possibility that HBV pathogenesis may be mediated in part via the interaction between HBx and AR.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Virology - Volume 363, Issue 2, 5 July 2007, Pages 454–461
نویسندگان
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