کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3426932 1227353 2007 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Extensive cross-reactive neutralizing antibody response in Indian patients with limited genetic diversity of HIV-1
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ویروس شناسی
پیش نمایش صفحه اول مقاله
Extensive cross-reactive neutralizing antibody response in Indian patients with limited genetic diversity of HIV-1
چکیده انگلیسی

Genome sequence analysis of HIV-1 subtype C viruses from India shows monophyletic lineage and relatively limited genetic diversity. To understand its immunological implication, cross-reactivity of neutralizing antibody response was investigated. In primary screening, neutralizing antibody response to single heterologous primary HIV-1 subtype C isolate was assessed in plasma samples from 235 HIV-1 infected, anti-retroviral treatment naive individuals from Pune, India. Plasma samples that showed ≥ 90% neutralization and two randomly selected plasma samples that showed 50–60% neutralization were tested against a panel of primary HIV-1 subtype C isolates obtained from epidemiologically unlinked individuals from India. The neutralizing antibody response showed extensive cross-neutralization, suggesting presence of shared neutralization determinants among circulating HIV-1 subtype C viruses in India.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Virology - Volume 359, Issue 2, 15 March 2007, Pages 295–301
نویسندگان
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