کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3427201 | 1227372 | 2006 | 11 صفحه PDF | دانلود رایگان |
The ability of several different influenza A virus strains to infect and replicate in primary, differentiated airway epithelial cell cultures from Syrian golden hamsters was investigated. All virus strains tested replicated equivalently in the cultures and displayed a preference for infecting nonciliated cells. This tropism correlated with the expression of both α2,3- and α2,6-linked sialic acid on the nonciliated cells. In contrast, the ciliated cells did not have detectable α2,6-linked sialic acid and expressed only low amounts of α2,3-linked sialic acid. In contrast to clinical isolates, laboratory strains of influenza A virus infected a limited number of ciliated cells at late times post-infection. The presence of α2,3- and α2,6-linked sialic acid residues on the same cell type suggests that Syrian golden hamsters and differentiated airway epithelial cell cultures derived from hamsters may provide a system for studying the reassortment of influenza A virus strains which utilize different forms of sialic acid as a primary virus receptor.
Journal: Virology - Volume 354, Issue 1, 10 October 2006, Pages 80–90