کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3427250 | 1227378 | 2007 | 10 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Analysis of the immune response of Hantaan virus nucleocapsid protein-specific CD8+ T cells in mice Analysis of the immune response of Hantaan virus nucleocapsid protein-specific CD8+ T cells in mice](/preview/png/3427250.png)
The major histocompatibility complex (MHC) class-I restricted epitope of Hantaan virus nucleocapsid protein (N) was identified using overlapping peptides and BALB/c mice. Using the MHC tetramer derived from the epitope, we found that the level of N-specific CD8+ T cells increased to approximately 20% of all antigen-specific CD8+ T cells in a mouse model of transient infection. However, N-specific CD8+ T cells were undetectable in a mouse model of persistent infection, both in the persistently infected phase and in the convalescent phase. Levels of CD8+ T cells producing interferon-γ were weak in both the acute and convalescent phases in the persistently infected model. These results indicate that hantavirus strongly suppresses the production of N-specific CD8+ T cells throughout the course of infection in persistently infected mice. Moreover, N-specific CD8+ T cells were not effective in recovering persistently infected mice, despite the existence of abundant N antigen in vivo.
Journal: Virology - Volume 365, Issue 2, 1 September 2007, Pages 292–301