کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3427487 | 1227399 | 2007 | 11 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: mda-5, but not RIG-I, is a common target for paramyxovirus V proteins mda-5, but not RIG-I, is a common target for paramyxovirus V proteins](/preview/png/3427487.png)
The induction of IFN-β by the paramyxovirus PIV5 (formerly known as SV5) is limited by the action of the viral V protein that targets the cellular RNA helicase mda-5. Here we show that 12 other paramyxoviruses also target mda-5 by a direct interaction between the conserved cysteine-rich C-terminus of their V proteins and the helicase domain of mda-5. The inhibition of IFN-β induction is not species-restricted, being observed in a range of mammalian cells as well as in avian cells, and we show that the inhibition of mda-5 function is also not restricted to mammalian cells. In contrast, the V proteins do not bind to the related RNA helicase RIG-I and do not inhibit its activity. The relative contributions of mda-5 and RIG-I to IFN-β induction are discussed.
Journal: Virology - Volume 359, Issue 1, 1 March 2007, Pages 190–200