کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3430745 1228283 2007 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Regulation of positive-strand RNA virus replication: The emerging role of phosphorylation
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ویروس شناسی
پیش نمایش صفحه اول مقاله
Regulation of positive-strand RNA virus replication: The emerging role of phosphorylation
چکیده انگلیسی

Protein phosphorylation is a reversible post-translational modification that plays a fundamental role in the regulation of many cellular processes. Phosphorylation can modulate protein properties such as enzymatic activity, stability, subcellular localization or interaction with binding partners. The importance of phosphorylation of the replication proteins of negative-strand RNA viruses has previously been documented but recent evidence suggests that replication of positive-strand RNA viruses – the largest class of viruses, including significant human, animal and plant pathogens – may also be regulated by phosphorylation events. The objective of this review is to summarize current knowledge regarding the various regulatory roles played by phosphorylation of nonstructural viral proteins in the replication of positive-strand RNA viruses.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Virus Research - Volume 129, Issue 2, November 2007, Pages 73–79
نویسندگان
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