کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3818398 1246367 2013 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Improvement of aminolevulinic acid (ALA)-mediated photodynamic diagnosis using n-propyl gallate
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی و دندانپزشکی (عمومی)
پیش نمایش صفحه اول مقاله
Improvement of aminolevulinic acid (ALA)-mediated photodynamic diagnosis using n-propyl gallate
چکیده انگلیسی

SummaryBackgroundPhotodynamic diagnosis (PDD) using aminolevulinic acid (ALA) is widely used in clinical fields. In PDD, protoporphyrin IX (PpIX) is generated from ALA in tumors, allowing the detection of the tumors by PpIX fluorescence. However, it is well known that PpIX is bleached by light irradiation (photobleaching) resulting in reduced PDD efficiency. In this study, n-propyl gallate (NPG) was investigated as an enhancer of PDD efficiency.MethodsTumor cells were incubated with NPG after treatment with ALA, and reactive oxygen species and PpIX fluorescence were measured.ResultsThe antioxidant NPG suppressed the production of reactive oxygen species from light-irradiated porphyrins and ameliorated photobleaching of PpIX generated from ALA in vitro and in vivo.ConclusionIncubation with NPG decreased the production of reactive oxygen species from PpIX and suppressed PpIX photobleaching. These results indicate that the antioxidant NPG may significantly improve PDD efficiency.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Photodiagnosis and Photodynamic Therapy - Volume 10, Issue 1, February 2013, Pages 28–32
نویسندگان
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