کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3840109 | 1247889 | 2015 | 26 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
MicroRNA expression profiles differentiate chronic pain condition subtypes
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کلمات کلیدی
IL-1RAVBDVestibulodyniaTMDIL-8miRNAsTMJIBSInterleukin 1 receptor antagonist - آنتاگونیست گیرنده اینترلوکین 1Temporomandibular disorder - اختلال تمپوروماندیبولارInterleukin 8 - اینترلوکین 8CNS - دستگاه عصبی مرکزیmicroRNAs - ریز آرانایirritable bowel syndrome - سندروم روده تحریک پذیر، کولیت عصبیcentral nervous system - سیستم عصبی مرکزیFibromyalgia - فیبرومیالژیاtemporomandibular joint - مفصل گیجگاهیhealthy controls - کنترل های سالم
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
پزشکی و دندانپزشکی (عمومی)
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
Chronic pain is a significant health care problem, ineffectively treated because of its unclear etiology and heterogeneous clinical presentation. Emerging evidence demonstrates that microRNAs (miRNAs) regulate the expression of pain-relevant genes, yet little is known about their role in chronic pain. Here, we evaluate the relationship among pain, psychological characteristics, plasma cytokines, and whole blood miRNAs in 22 healthy controls (HCs); 33 subjects with chronic pelvic pain (vestibulodynia, VBD); and 23 subjects with VBD and irritable bowel syndrome (VBDÂ +Â IBS). VBD subjects were similar to HCs in self-reported pain, psychological profiles, and remote bodily pain. VBDÂ +Â IBS subjects reported decreased health and function; and an increase in headaches, somatization, and remote bodily pain. Furthermore, VBD subjects exhibited a balance in proinflammatory and anti-inflammatory cytokines, whereas VBDÂ +Â IBS subjects failed to exhibit a compensatory increase in anti-inflammatory cytokines. VBD subjects differed from controls in expression of 10 miRNAs of predicted importance for pain and estrogen signaling. VBDÂ +Â IBS subjects differed from controls in expression of 11 miRNAs of predicted importance for pain, cell physiology, and insulin signaling. miRNA expression was correlated with pain-relevant phenotypes and cytokine levels. These results suggest that miRNAs represent a valuable tool for differentiating VBD subtypes (localized pain with apparent peripheral neurosensory disruption vs widespread pain with a central sensory contribution) that may require different treatment approaches.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Translational Research - Volume 166, Issue 6, December 2015, Pages 706-720.e11
Journal: Translational Research - Volume 166, Issue 6, December 2015, Pages 706-720.e11
نویسندگان
Brittney P. Ciszek, Asma A. Khan, Hong Dang, Gary D. Slade, Shad Smith, Eric Bair, William Maixner, Denniz Zolnoun, Andrea G. Nackley,