کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3840240 1247899 2013 15 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
T cell-based gene therapy of cancer
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی و دندانپزشکی (عمومی)
پیش نمایش صفحه اول مقاله
T cell-based gene therapy of cancer
چکیده انگلیسی

Adoptive immunotherapy using gene engineered T cells is a promising and rapidly evolving field, and the ability to engineer T cells to manifest desired phenotypes and functions has become a practical reality. In this review, we describe and summarize current thought about gene engineering of T cells. We focus on the identified requirements for the successful application of T cell based immunotherapy and discuss gene-therapy based strategies that address these requirements and have the potential to enhance the successful implementation of this promising approach to treat cancer.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Translational Research - Volume 161, Issue 4, April 2013, Pages 365–379
نویسندگان
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