کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3896447 1250218 2013 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Epigenetic Alterations in Acute Kidney Injury
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیماری‌های کلیوی
پیش نمایش صفحه اول مقاله
Epigenetic Alterations in Acute Kidney Injury
چکیده انگلیسی
Acute kidney injury (AKI) is a risk factor for chronic kidney disease and death. Despite progress made in understanding the cellular and molecular basis of AKI pathogenesis there has been no improvement in the high mortality rate from this disease in decades. Epigenetics is one of the most intensively studied fields of biology today and represents a new paradigm for understanding the pathophysiology of disease. Although epigenetics of AKI is a nascent field, the available information already is providing compelling evidence that chromatin biology plays a critical role in this disease. In this article we explore what is known about the contribution of epigenetic mechanisms to the pathophysiology of AKI and how this knowledge already is guiding the development of new diagnostic tools and epigenetic therapies.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Nephrology - Volume 33, Issue 4, July 2013, Pages 327-340
نویسندگان
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