Anatomic structure-based deformable image registration of brachytherapy implants in the treatment of locally advanced cervix cancer

We have investigated the use of structure-based CT image sets for image registrations and have produced anatomically favorable registrations with excellent matching of external contours as compared to registrations of original grayscale images. Commercial software registrations using treatment-planning structures required no manual tweaking on a per-patient basis, suggesting results are reproducible and broadly applicable.