Dosimetric comparison of 192Ir high-dose-rate brachytherapy vs. 50Â kV x-rays as techniques for breast intraoperative radiation therapy: Conceptual development of image-guided intraoperative brachytherapy using a multilumen balloon applicator and in-room

Image-guided HDR intraoperative brachytherapy with a multilumen balloon applicator provides superior target volume coverage compared with 50 kV photons, while maintaining doses within tolerance limits for normal tissues. An ongoing prospective clinical trial will evaluate the safety and feasibility of this technique.