Evaluation of radiobiologic biochemical control in a large permanent prostate brachytherapy population from a single institution using AAPM TG-137 parameters

In a large prostate implant population, dosimetric and derived radiobiologic parameters did not predict for failure. Apparently, too few patients had total BEDs below the level necessary for optimum biochemical control. A learning curve extended over hundreds of patients before plateauing but changes in seed characterization parameters also had a pronounced effect.