کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3978588 | 1257289 | 2013 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Rôle du pathologiste dans la prise en charge des tissus en oncologie
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کلمات کلیدی
BiomarqueurIn situ hybridization - Hybridization در محلFixative - اصلاح کنندهcongélation - انجمادImmunohistochemistry - ایمونوهیستوشیمیImmunohistochimie - ایمونوهیستوشیمیBiopsie - بافت برداریBiopsy - بافتبرداری یا بیوپسیBiomarker - بیومارکرBiologie moléculaire - زیست شناسی مولکولیMolecular biology - زیستشناسی مولکولیHybridation in situ - هیبریداسیون در محل
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
تومور شناسی
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چکیده انگلیسی
Currently, the increasing number of ancillary methods to be performed from tumoral tissues in a pathology laboratory determines the necessity to have an optimal strategy for tissue management. The size of tissue samples dedicated for a pathological examination becomes smaller and smaller, as the diagnosis can be made with non or less invasive methods. However, the samples should also allow to provide the prognosis as well as to realise biological molecular testing in order to found a genomic alteration. Thus, it is critical to think about how to share and to pool the different expertises and abilities in a pathology laboratory in order to optimize the achievement of the different ancillary methods. Thus, following the morphological study made in hematoxylin-eosin staining, it is necessary to preempt the number of immunohistochemical and in situ hybridization studies, which will be potentially done from the tissue samples. Moreover, since the genomic alteration detection in tumours is mainly performed from DNA extracted from tissues, it is necessary to take in account some numerous parameters, in particular the nature and the time of fixation, the percentage of tumour cells, the presence of necrotic area, the percentage of inflammatory cells and the sample size. The strategy for an optimal tissue management in an oncology-pathology laboratory is critical and takes part of the different steps allowing to get an accreditation according the ISO15189 norm.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bulletin du Cancer - Volume 100, Issue 9, September 2013, Pages 837-845
Journal: Bulletin du Cancer - Volume 100, Issue 9, September 2013, Pages 837-845
نویسندگان
Ãlodie Long, Marius Ilie, Véronique Hofman, Sandra Lassalle, Catherine Butori, Saad Alsubaie, Paul Hofman,