کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3978610 | 1257290 | 2013 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Analyse comparative des coûts de techniques de biologie moléculaire dans le diagnostic de sarcomes
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
تومور شناسی
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چکیده انگلیسی
Sarcomas represent a complex and heterogeneous group of rare malignant tumors and their correct diagnosis is often difficult. Recent molecular biological techniques have been of great diagnostic use and there is a need to assess the cost of these procedures in routine clinical practice. Using prospective and observational data from eight molecular biology laboratories in France, we used “microcosting” method to assess the cost of molecular biological techniques in the diagnosis of five types of sarcoma. The mean cost of fluorescence in situ hybridization (FISH) was 318 ⬠(273-393) per sample; mean reverse transcription polymerase chain reaction (RT-PCR) cost ranged from 300 ⬠(229-481) per formalin-fixed, paraffin-embedded specimen to 258 ⬠(213-339) per frozen specimen; mean quantitative polymerase chain reaction (Q-PCR) cost was 184 ⬠(112-229) and mean CGH-array cost was 332 ⬠(329-335). The cost of these recently implemented techniques varied according to the type of sarcoma; the method of tissue collection and local organizational factors including the level of local expertise and investment. The cost of molecular diagnostic techniques needs to be balanced against their respective performance.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bulletin du Cancer - Volume 100, Issue 10, October 2013, Pages 963-971
Journal: Bulletin du Cancer - Volume 100, Issue 10, October 2013, Pages 963-971
نویسندگان
Sandrine Baffert, Antoine Italiano, Gaëlle Pierron, Marie-Angèle Traoré, Jocelyn Rapp, Fabienne Escande, Jean-Pierre Ghnassia, Philippe Terrier, Anne-Claire Voegeli, Dominique Ranchere-Vince, Jean-Michel Coindre, Florence Pedeutour,