کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3978656 1257292 2012 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Complications neurologiques centrales des chimiothérapies cytotoxiques et des thérapies ciblées
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی تومور شناسی
پیش نمایش صفحه اول مقاله
Complications neurologiques centrales des chimiothérapies cytotoxiques et des thérapies ciblées
چکیده انگلیسی
Anti-cancer treatments (cytotoxic chemotherapies, targeted therapies and hormonotherapies) are known to induce early and delayed neurological toxicities. Acute encephalopathies and posterior reversible encephalopathies are better known and described, physiopathological hypotheses are emerging. It is difficult to discriminate what drug is causing the symptoms in patients treated with multiple cytotoxic drugs. Methotrexate and ifosfamide are responsible for acute encephalopathies. l-asparaginase and methotrexate or targeted therapies may induce cerebrovascular complications. As life expectancy increases and more complex regimen including innovative targeted therapies are developed, new toxicity profiles can be expected. To be able to provide an early diagnosis, prevention, and treatment (when existing) of these pathologies remains a tremendous challenge that would allow a good quality of life with social and professional life after their cancer is cured.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bulletin du Cancer - Volume 99, Issue 9, September 2012, Pages 851-863
نویسندگان
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