کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3980249 | 1257421 | 2012 | 9 صفحه PDF | دانلود رایگان |
BackgroundDifferent modalities of treatment in early laryngeal cancer lead to equivalent oncological outcomes. Hence this systematic review was undertaken to synthesise the key oncological outcomes following primary open partial laryngectomy for laryngeal cancer.MethodsA systematic review of the English literature with statistical pooling of outcomes, the main outcome measure being local control at 24 months.ResultsA total of 53 articles satisfied inclusion criteria and were included in the review. The pooled local control rate at 24 months from 5061 patients was 89.8% (95% CI 88.3–91.2), pooled overall survival was 79.7% (n = 3967; 95% CI 76.5–782.8) and pooled mean disease free survival was 84.8% (n = 2344; 95% CI 80.6–88.7). The pooled mean operative mortality, laryngectomy for function, tracheostomy decannulation and permanent gastrostomy rates were 0.7%, 1.7%, 96.3%, and 2.0%, respectively.ConclusionsOpen conservation laryngectomy is a good option in selected primary laryngeal cancers with excellent oncological outcomes.
Journal: Cancer Treatment Reviews - Volume 38, Issue 3, May 2012, Pages 203–211