کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3981319 | 1257678 | 2016 | 8 صفحه PDF | دانلود رایگان |
• Cervical cancer patients who underwent hysterectomy were analyzed on MRI and pathology for involvement of the internal os.
• Distance of the tumor from the internal-os was measured on MRI and Pathology and findings were tabulated as > and ≤ 5 mm from the internal os.
• MRI has the ability to identify tumor involvement of the internal os.
• MRI can help select patients who can undergo trachelectomy safely.
AimTo determine the ability of magnetic resonance imaging (MRI) in detecting tumour-free margins from the internal os (IO).Materials and methodsA database search yielded 79 women with early-stage cervical cancer who underwent radical hysterectomy and preoperative MRI. The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy of MRI in assessment of ≤5 and >5 mm IO involvement were calculated with histopathological surgical specimen findings considered to be the reference standard. A main and subset analysis was performed. The subset analysis included only those patients who would have been considered for radical trachelectomy.ResultsFor predicting a distance between the tumour and the IO of ≤5 mm, MRI had a sensitivity of 73%, a specificity of 98.3%, a PPV of 95%, a NPV of 88.1%, and an accuracy of 89.8% for the main analysis, and sensitivity of 81.8%, a specificity of 93.2% a PPV of 69.2% a NPV of 96.5% and an accuracy of 91.4% for the subset analysis.ConclusionMRI has high specificity, NPV, and accuracy in detecting tumour from the IO, making MRI suitable for treatment planning in patients desiring trachelectomy to preserve fertility.
Journal: Clinical Radiology - Volume 71, Issue 6, June 2016, Pages 515–522