کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3981515 1257692 2015 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Metastatic patterns of breast cancer subtypes: What radiologists should know in the era of personalized cancer medicine
ترجمه فارسی عنوان
الگوهای متاستاتیک زیرمجموعههای سرطان پستان: چه رادیولوژیستها باید در دوران پزشکی سرطان فردی بدانند
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی تومور شناسی
چکیده انگلیسی

There is accumulating evidence that molecular phenotyping of breast cancer determines the timing, pattern, and outcome of metastatic disease. The most clinically relevant subtypes are hormonal-positive [oestrogen and progesterone receptor (ER/PR) positive], HER2 expressing, and triple-negative breast cancers (TNBCs). ER/PR-positive breast cancers demonstrate the best prognosis; however, metastases, in particular osseous disease, may develop much later. HER2-expressing breast cancers, although aggressive, have improved outcomes due to the advent of HER2-targeted therapies, with increased risk of central nervous system (CNS) relapses later. Finally, TNBCs present in younger women, BRCA1 mutations carriers, and carry the worst overall prognosis, with high incidence of CNS metastases, especially during the first 5 years of diagnosis. It is important for radiologists to understand the nuances of these breast cancer subtypes to predict metastatic behaviours and guide possible imaging surveillance.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Radiology - Volume 70, Issue 1, January 2015, Pages 1–10
نویسندگان
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