کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3981519 1257692 2015 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Multivoxel proton magnetic resonance spectroscopy in heat stroke
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی تومور شناسی
پیش نمایش صفحه اول مقاله
Multivoxel proton magnetic resonance spectroscopy in heat stroke
چکیده انگلیسی


• Proton magnetic resonance spectroscopy offers important information in patients with heat stroke.
• Significantly different NAA/Cr ratios were found between heat stroke and controls.
• The severity of heat stroke can be effectively evaluated by NAA/Cr ratios.

AimTo assess the role of proton MR spectroscopy (MRS) in the detection of changes in metabolite levels of the cerebellum after heat stroke (HS).Materials and methodsThe study group consisted of eight patients after HS, with a Glasgow Coma Scale (GCS) score of 3–9. The MR studies were performed with a 1.5 T system. MR spectra were recorded from a normal-appearing cerebellum region. Spectra from patients were compared with a control group including seven age-matched healthy volunteers recorded with the same techniques. Metabolites ratios including N-acetyl aspartate/creatine (NAA/Cr), N-acetyl aspartate/creatine2 (NAA/Cr2), choline/creatine (Cho/Cr), choline/creatine2 (Cho/Cr2), and N-acetyl aspartate/choline (NAA/Cho) were calculated and the differences between the two groups were evaluated using the Mann–Whitney U-test. Pearson correlation analysis was used to analyse the relationship between NAA/Cr ratios and GCS scores for eight patients after HS.ResultsIn the cerebellum of the patients after HS, NAA/Cr ratios were found to be significantly decreased compared to normal controls (p = 0.004) and Cho/Cr ratios were found to be decreased compared to normal controls (p = 0.032). Significant positive correlation was found between NAA/Cr ratios and GCS scores for eight patients after HS (r = 0.748, p = 0.033).ConclusionsMetabolite abnormalities were seen in normal-appearing cerebellum structures in patients after HS. Proton MRS is a useful tool for evaluating major changes in metabolite levels of the cerebellum after HS and the severity of the disease can be effectively evaluated by NAA/Cr ratios.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Radiology - Volume 70, Issue 1, January 2015, Pages 37–41
نویسندگان
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