کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3981736 1257703 2014 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Relationship between CT features and high preoperative serum carcinoembryonic antigen levels in early-stage lung adenocarcinoma
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی تومور شناسی
پیش نمایش صفحه اول مقاله
Relationship between CT features and high preoperative serum carcinoembryonic antigen levels in early-stage lung adenocarcinoma
چکیده انگلیسی

AimTo assess the relationship between thin-section computed tomography (CT) features of primary tumour and high preoperative serum carcinoembryonic antigen (CEA) levels that reportedly suggest poor prognoses in early-stage lung adenocarcinoma.Materials and methodsTwo hundred and seventy-five consecutive patients who underwent resection of pathological stage I (T1–2aN0M0) adenocarcinomas with a maximum diameter of ≤3 cm (144 men, 131 women; mean age 67.8 years) were enrolled. CT features of the primary tumours and clinical characteristics of these patients were statistically evaluated to identify the factors associated with high serum CEA levels (>5 ng/ml).ResultsEighty-one patients (29.5%) had high serum CEA levels. In univariate analysis, lower ground-glass opacity ratio (p < 0.001), lower tumour shadow disappearance rate (TDR: the ratio of tumour area in mediastinal window to that of lung window, p < 0.001), presence of notch (p = 0.015), and coexistence with bullae or honeycomb cysts (p < 0.001) were observed more frequently in the group with high serum CEA levels than that of the group with normal levels. TDR [odds ratio (OR) 0.984; 95% confidence interval (CI): 0.976–0.993; p < 0.001] and coexistence with bullae or honeycomb cysts (OR = 3.08; 95% CI: 1.55–6.12; p = 0.001) remained significant, even after adjusting patients' age, gender, and smoking status.ConclusionsAdenocarcinomas with lower TDR and coexisting with bullae or honeycomb cysts are associated with high preoperative serum CEA levels. Although some CEA elevations may be due to benign pulmonary diseases, such tumours are suspected to have poor prognoses, even for early-stage diseases.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Radiology - Volume 69, Issue 6, June 2014, Pages 559–566
نویسندگان
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