کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3982049 1257714 2014 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Microstructure assessment of the thalamus in Wilson's disease using diffusion tensor imaging
ترجمه فارسی عنوان
ارزیابی ریز ساختار تالاموس در بیماری ویلسون با استفاده از تصویربرداری تانسور منتشر
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی تومور شناسی
چکیده انگلیسی

AimTo assess diffusion changes of the thalamus in Wilson's disease using diffusion tensor imaging (DTI).Materials and methodsFifteen patients with Wilson's disease and an abnormal signal in the thalamus (designated as group 1) and 18 patients with Wilson's disease with a normal-appearing thalamus (designated as group 2) at conventional magnetic resonance imaging (MRI) were recruited. Fifteen age-matched and sex-matched healthy volunteers were also enrolled as the control group (designated as group 3). The fractional anisotropy (FA), primary eigenvalue (λ1), second eigenvalue (λ2), and third eigenvalue (λ3) of the thalamus were measured and the differences were compared.ResultsThe FA values of the thalamus were different in the three groups (group 1: 0.36 ± 0.02; group 2: 0.38 ± 0.02; group 3: 0.43 ± 0.02; F = 54.51, p < 0.001). A statistically significant difference was observed between group 1 and group 2 (p = 0.003), group 1 and group 3 (p = 0.001), and group 2 and group 3 (p < 0.001). The λ1, λ2, and λ3 values of the thalamus were different in the three groups (1.11 ± 0.06 mm2/s, 1.11 ± 0.06 mm2/s, and 1.10 ± 0.04 mm2/s of λ1 in group 1, group 2, and group 3, respectively; 0.82 ± 0.08 mm2/s, 0.78 ± 0.05 mm2/s, and 0.72 ± 0.02 mm2/s of λ2 in group 1, group 2, and group 3, respectively; 0.52 ± 0.05 mm2/s, 0.49 ± 0.06 mm2/s, and 0.42 ± 0.06 mm2/s of λ3 in group 1, group 2, and group 3, respectively; F = 1.65, p = 0.203 of λ1; F = 10.55, p < 0.001 of λ2; F = 4.21, p = 0.021 of λ3; respectively). A statistically significant difference in the λ2 value was observed between group 1 and group 3 (p < 0.001) and group 2 and group 3 (p = 0.005). A statistically significant difference in the λ3 value was also observed between group 1 and group 3 (p = 0.007). No significant difference in the λ1 value was noted between each of the two groups.ConclusionsDamage of the thalamus in Wilson's disease patients can be detected using DTI. DTI may provide information regarding thalamus damage in patients with Wilson's disease before abnormal signals on conventional MRI.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Radiology - Volume 69, Issue 3, March 2014, Pages 294–298
نویسندگان
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