کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3983804 1257781 2007 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Mammographic bi-dimensional product: a powerful predictor of successful excision of ductal carcinoma in situ
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی تومور شناسی
پیش نمایش صفحه اول مقاله
Mammographic bi-dimensional product: a powerful predictor of successful excision of ductal carcinoma in situ
چکیده انگلیسی

BackgroundThe aim of this analysis was to ascertain whether uni-dimensional measurement of mammographic microcalcification, the product of bi-dimensional measurement, calcification morphology, and pathological grade are helpful in predicting successful single therapeutic wide local excision (WLE) of ductal carcinoma in situ (DCIS).MethodsThe study group comprised 505 patients whose mammograms showed the DCIS as calcification, and in whom a non-operative diagnosis had been obtained and WLE attempted. The extents of mammographic calcifications was measured in two planes at 90° on the oblique view, the appearances classified as comedo, granular, or punctate. DCIS was graded using cyto-nuclear characteristics.ResultsThree hundred and forty-two patients had a successful first WLE and 163 patients had further surgery. A uni-dimensional measurement of <35 mm and a bi-dimensional product of <800 mm2 were associated with successful excision (69 versus 54%, p = 0.02 and 70 versus 27%, p = 0.0001, respectively). Mammographic calcification morphology and histological grade did not influence the likelihood of a successful first WLE. For high-grade DCIS, the upper limit of the bi-dimensional product associated with successful WLE was 800 mm2 (69 versus 24%, p = 0.0003). In contrast, for non-high-grade DCIS, the cut-off was 400 mm2 (73 versus 33%, p = 0.01). Analyses based on mammographic calcification morphology gave similar findings.ConclusionThe mammographic bi-dimensional product is a powerful predictor of successful WLE of DCIS when combined with histological grade and/or calcification morphology.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Radiology - Volume 62, Issue 8, August 2007, Pages 787–791
نویسندگان
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