کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3983981 1257791 2009 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Diffusion-weighted imaging in predicting and monitoring the response of uterine cervical cancer to combined chemoradiation
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی تومور شناسی
پیش نمایش صفحه اول مقاله
Diffusion-weighted imaging in predicting and monitoring the response of uterine cervical cancer to combined chemoradiation
چکیده انگلیسی

AimTo investigate the ability of diffusion-weighted imaging (DWI) to predict and monitor the response of uterine cervical cancer to combined chemoradiation using apparent diffusion coefficients (ADCs).Materials and methodsSeventeen women (mean age 48.5 years) with uterine cervical cancer received conventional magnetic resonance imaging (MRI) and DWI prior to chemoradiation and after 1 and 2 months of therapy. A subgroup of eight also had MRI and DWI repeated after 15 days of therapy. Treatment response was determined according to changes in tumour size after 2 months of therapy and was classified as complete response (CR), partial response (PR), stable disease (SD), or progressive disease (PD). Pretreatment ADCs were compared between the different disease response groups, and dynamic changes of ADCs in each group were observed. Pearson's correlation test was calculated between those ADC parameters and tumour response.ResultsPretreatment ADCs for CR were significantly lower than those of PR (p = 0.005). Negative correlation was found between pretreatment ADCs and percentage size reduction after 2 months of chemoradiation (p = 0.016). The percentage ADC change after 1 month correlated positively with percentage size reduction after 2 months of therapy (p = 0.021). ADCs after 15 days of therapy increased significantly compared with pretreatment ones (p = 0.001); however, the longest tumour diameter showed no statistically significant change (p = 0.078).ConclusionADCs may have the potential to be used to predict and monitor the response of uterine cervical cancer to therapy.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Radiology - Volume 64, Issue 11, November 2009, Pages 1067–1074
نویسندگان
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