کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3985687 | 1601395 | 2013 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Disease-related surgery in patients with distant metastatic breast cancer Disease-related surgery in patients with distant metastatic breast cancer](/preview/png/3985687.png)
IntroductionThis study evaluates the frequency of and indications for disease-related surgical procedures in the palliative breast cancer (BC) situation.Patients & methodsBased on a cohort of women who were treated for newly diagnosed BC during a 20-year period (1990–2009), we analyzed 340 patients who developed distant metastatic disease (DMD) until 2011 and died (i.e. still ongoing palliative disease courses were not included).ResultsOne hundred and twenty-seven surgical procedures were performed in 100 patients (29.4% of all patients with metastatic disease). The most common site for surgery was breast (n = 60, 47.2%). The primary tumor was removed at first diagnosis of DMD in 43 patients (33.9%); sixteen operations (12.6%) were performed for local recurrence. In 37 patients, 50 surgical procedures (39.4%) were necessary to stabilize osseous structures due to metastases. Procedures were rarely performed on other common metastatic sites: lung: n = 1 (0.8%); liver: n = 1 (0.8%), brain: n = 4 (3.1%). When excluding surgery for primary breast tumors at initial diagnosis of DMD from analysis, 34 of 84 surgeries (40.4%) were performed in the first third of survival follow-up (i.e. period of metastatic disease survival); operations in the last two-thirds each totaled 29.8% (n = 25). The median survival after surgery was 16 months (range: 0.5–89 months).ConclusionsIn a cohort of BC patients who had primary or developed secondary DMD, nearly one third of the patients received disease-related surgical procedures during their palliative disease course. This high rate of operations shows that surgery has a clearly established role in the palliative therapy concept.
Journal: European Journal of Surgical Oncology (EJSO) - Volume 39, Issue 11, November 2013, Pages 1192–1198