کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3986552 1601425 2011 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The clinical significance of circulating tumor cells in non-metastatic colorectal cancer – A review
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی تومور شناسی
پیش نمایش صفحه اول مقاله
The clinical significance of circulating tumor cells in non-metastatic colorectal cancer – A review
چکیده انگلیسی

BackgroundFinding a clinical tool to improve the risk stratification and identifying those colorectal cancer patients with an increased risk of recurrence is of great importance. The presence of circulating tumor cells (CTC) in peripheral blood can be a strong marker of poor prognosis in patients with metastatic disease, but the prognostic role of CTC in non-metastatic colorectal cancer is less clear. The aim of this review is to examine the possible clinical significance of circulating tumor cells in non-metastatic colorectal cancer (TNM-stage I–III) with the primary focus on detection methods and prognosis.MethodsThe PubMed and Cochrane database and reference lists of relevant articles were searched for scientific literature published in English from January 2000 to June 2010. We included studies with non-metastatic colorectal cancer (TNM-stage I–III) and CTC detected pre- and/or post-operatively in peripheral blood.ResultsNine studies qualified for further analyses. Detection rates of CTC in peripheral blood of patients with non-metastatic colorectal cancer varied from 4% to 57%. Seven studies applied RT-PCR and two studies used immunocytochemical methods. Seven studies found the presence of CTC to be a prognostic marker of poor disease-free survival.ConclusionThe presence of CTC in peripheral blood is a potential marker of poor disease-free survival in patients with non-metastastic colorectal cancer. The low abundance of CTC in non-metastatic colorectal cancer requires very sensitive and specific detection methods. An international consensus on choice of detection method and markers, is warranted before incorporating CTC into risk stratification in the clinical setting.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Surgical Oncology (EJSO) - Volume 37, Issue 6, June 2011, Pages 459–465
نویسندگان
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