کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3987031 1601438 2010 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Systematic review and meta-analysis of the association between P53 codon 72 polymorphism and colorectal cancer
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی تومور شناسی
پیش نمایش صفحه اول مقاله
Systematic review and meta-analysis of the association between P53 codon 72 polymorphism and colorectal cancer
چکیده انگلیسی

BackgroundA number of studies has evaluated the association between P53 codon 72 polymorphism and colorectal cancer. However, results were inconsistent. To clarify the role of this polymorphism in colorectal cancer, we conducted a meta-analysis on this topic.MethodsTwo authors independently searched the PubMed and EMBASE database from 1966 to January 2010 for studies regarding the association of P53 codon 72 polymorphism with colorectal cancer. Summary odds ratios with their corresponding 95% confidence intervals were calculated by using random-effects model.ResultsThe combined results showed that P53 codon 72 variant genotypes were not associated with colorectal cancer risk when compared to Arg/Arg genotype (Pro/Pro: OR = 1.02, 95% CI = 0.80–1.29; Arg/Pro: OR = 1.00, 95% CI = 0.86–1.16; Pro allele: OR = 1.00, 95% CI = 0.86–1.17). When stratifying for study population, design and cancer location, no statistically significant results were observed either.ConclusionOur data indicate that the P53 codon 72 polymorphism may be not associated with colorectal cancer risk.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Surgical Oncology (EJSO) - Volume 36, Issue 5, May 2010, Pages 431–438
نویسندگان
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