کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3987738 1601476 2007 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Palliation for suspected unresectable hilar cholangiocarcinoma
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی تومور شناسی
پیش نمایش صفحه اول مقاله
Palliation for suspected unresectable hilar cholangiocarcinoma
چکیده انگلیسی

AimThe aim of this study was to evaluate the outcome of different techniques of palliation for patients with hilar cholangiocarcinoma.MethodAll patients treated with palliative intent between 1988 and 2004 at the Royal Infirmary of Edinburgh were reviewed. Patients were analysed on an intention to treat basis. Demographics, procedure and outcome (including re-admissions) were recorded.ResultsTwo hundred and thirty-three patients underwent palliative treatment for suspected hilar cholangiocarcinoma. The diagnosis was confirmed histologically in 109 patients. The procedure related morbidity and mortality was 54/225 and 18/207 respectively. Seventy-one patients required re-admission. Twenty patients underwent surgical biliary bypass for jaundice. Those undergoing surgical palliation had a longer median (95% CI) time to re-admission (16 (0–36) vs.7 (2–12) weeks, p = 0.001). Endoscopic retrograde cholangio-pancreatography (ERCP) and stenting was only successful in 28 patients and was associated with a significantly higher re-admission rate compared to patients in whom ERCP was not performed (60/179 vs. 4/27, p = 0.050). The overall median (95% CI) survival was 145 (124–185) days.ConclusionCurrent options for palliation of hilar cholangiocarcinoma provide good short term success but are all associated with significant early and late morbidity. Due to its low success and association with an increased re-admission rate, ERCP for definitive palliation should not be used in the first line staging and management of these patients.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Surgical Oncology (EJSO) - Volume 33, Issue 3, April 2007, Pages 341–345
نویسندگان
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