کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3987739 | 1601476 | 2007 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Number of positive lymph nodes independently affects long-term survival after resection in patients with ampullary carcinoma Number of positive lymph nodes independently affects long-term survival after resection in patients with ampullary carcinoma](/preview/png/3987739.png)
AimThe nodal status is an established prognostic factor in ampullary carcinoma. The aim of this study was to compare the prognostic power of the anatomic location of positive nodes with that of the number of positive nodes.MethodsOf 73 consecutive patients treated for ampullary carcinoma, 62 underwent pancreaticoduodenectomy with regional lymphadenectomy. A survival analysis of these 62 patients by nodal status was conducted retrospectively. A total of 1942 lymph nodes taken from the patients were examined histologically for metastasis. The location of positive regional nodes was classified into 4 categories, according to the Japanese staging system. The number of positive regional nodes was recorded for each patient. The median follow-up period was 124 months.ResultsNodal disease was found in 31 patients, of whom 23 had 1–3 positive regional nodes and 8 had ≥4 positive regional nodes. Univariate analysis revealed that both the location (p < 0.0001) and the number (p < 0.0001) of positive nodes were significant prognostic factors. Multivariate analysis revealed that the number of positive nodes was an independent prognostic factor (p = 0.007), while the location failed to remain as an independent variable. The median survival time was 59 months with a 5-year survival rate of 48% in patients with 1–3 positive nodes, whereas all patients with ≥4 positive nodes died of the disease within 29 months of resection (p = 0.0001).ConclusionThe number, not the location, of positive regional lymph nodes independently affects long-term survival after resection in patients with ampullary carcinoma.
Journal: European Journal of Surgical Oncology (EJSO) - Volume 33, Issue 3, April 2007, Pages 346–351