کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3987810 | 1601475 | 2007 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: A systematic review on the significance of extracapsular lymph node involvement in gastrointestinal malignancies A systematic review on the significance of extracapsular lymph node involvement in gastrointestinal malignancies](/preview/png/3987810.png)
AimsThe impact of extracapsular lymph node involvement (LNI) has been studied for several malignancies, including gastrointestinal malignancies. Aim of this study was to assess the current evidence on extracapsular LNI as a prognostic factor for recurrence in gastrointestinal malignancies.MethodsThe Cochrane Database of systematic reviews, the Cochrane central register of controlled trials, and MEDLINE databases were searched using a combination of keywords relating to extracapsular LNI in gastrointestinal malignancies. Primary outcome parameters were incidence of extracapsular LNI and overall five-year survival rates.FindingsFourteen manuscripts were included, concerning seven oesophageal, three gastric, one colorectal, and three rectal cancer series with a total of 1528 node positive patients. The pooled incidence of extracapsular LNI was 57% (95% CI: 53–61%) for oesophageal cancer, 41% (95% CI: 36–47%) for gastric cancer, and 35% (95% CI: 31–40%) for rectal cancer. In nine of the 14 studies a multivariate analysis was performed. In eight of these nine studies extracapsular LNI was identified as an independent risk factor for recurrence.ConclusionExtracapsular LNI is a common phenomenon in patients with gastrointestinal malignancies. It identifies a subgroup of patients with a significantly worse long-term survival. This systematic review highlights the importance of assessing extracapsular LNI as a valuable prognostic factor. Pathologists and clinicians should be aware of this important feature.
Journal: European Journal of Surgical Oncology (EJSO) - Volume 33, Issue 4, May 2007, Pages 401–408