کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3987827 1601475 2007 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Contribution of surgery in patients with bulky residual disease after chemoradiation for advanced cervical carcinoma
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی تومور شناسی
پیش نمایش صفحه اول مقاله
Contribution of surgery in patients with bulky residual disease after chemoradiation for advanced cervical carcinoma
چکیده انگلیسی

AimTo report the outcome of 30 patients who underwent surgery after concomitant chemoradiation for locally advanced cervical cancer with residual disease ≥2 cm.MethodsFrom 1988 to 2004, 143 patients with FIGO stage IB2–IVA cervical cancer underwent surgery after concurrent chemoradiotherapy. Among them, 30 had a residual cervical tumour ≥2 cm prior to surgery. Surgery consisted in a simple or radical hysterectomy (n = 15) or in a pelvic exenteration (n = 15). Endpoints were recurrence and distant metastasis rates, overall survival (OS) and disease-free survival (DFS) at 3 and 5 years. Analysis included FIGO stage, response to chemoradiation, para-aortic lymphatic status or type of surgery: palliative (remaining disease after surgery) or curative (no evidence of remaining disease after surgery).ResultsSurgery has been only palliative in 11 cases. Pelvic recurrences occurred in 8 patients after a median interval of 8.8 months. Distant metastases occurred in 8 patients after a median interval of 13 months. So far, 16 patients have died (53.3%). The 3-year and 5-year OS rates are 64.9% and 55.6%, respectively, for the 19 patients who had a curative surgery. The DFS rate is 50.8% at 3 and 5 years in this latter group. Overall 12 patients (40%) are alive and free of disease after a median follow-up of 32.5 months.ConclusionsAdjuvant surgery may improve the outcome of patients with bulky residual tumour after chemoradiation for locally advanced cervical cancer, allowing a 5-year OS of 55.6% after curative intervention.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Surgical Oncology (EJSO) - Volume 33, Issue 4, May 2007, Pages 498–503
نویسندگان
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