کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3987847 | 1601467 | 2008 | 7 صفحه PDF | دانلود رایگان |
AimsCD4+ CD25+ forkhead box P3 (FOXP3)+ Treg accumulate in malignant tumors and negatively regulate anti-tumor immunity. To determine the prognostic value of tumor-infiltrating regulatory T cells (Treg), we conducted a retrospective study on 164 patients with hepatocellular carcinoma (HCC) who underwent curative hepatic resection.MethodsWe investigated the number of tumor-infiltrating FOXP3+ Treg in formalin-fixed HCC specimens. The number of FOXP3+ Treg for each case was calculated as the total number of positive cells per 10 high-power fields (HPF) on light microscopy. Long-term survival rate after resection according to the number of FOXP3+ Treg was accessed by univariate and multivariate analyses.ResultsThe mean and median numbers of tumor-infiltrating Treg were 29.0 and 14 per 10 HPF for FOXP3+ Treg. The number of FOXP3+ Treg was positively correlated with preoperative serum alpha-fetoprotein levels. The disease-free survival rate was significantly lower in patients with high Treg counts (≥14, n = 84) than in those with low Treg counts (<14, n = 80) (13.6% vs. 25.7% at 5 years; P = 0.02). By multivariate analysis, the high Treg counts, presence of portal vein invasion, and elevation of preoperative aspartate aminotransferase level were independent predictive factors of tumor recurrence.ConclusionsThe high number of tumor-infiltrating Treg is an independent predictive factor of tumor recurrence after hepatic resection for HCC.
Journal: European Journal of Surgical Oncology (EJSO) - Volume 34, Issue 2, February 2008, Pages 173–179