کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3987906 1601488 2006 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Correlation between copy number of mitochondrial DNA and clinico‐pathologic parameters of hepatocellular carcinoma
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی تومور شناسی
پیش نمایش صفحه اول مقاله
Correlation between copy number of mitochondrial DNA and clinico‐pathologic parameters of hepatocellular carcinoma
چکیده انگلیسی

AimsIn the current study, we investigated possible correlations of the mtDNA copy number in hepatocellular carcinoma (HCC) with the pathological findings and prognosis.MethodsWe studied 31 HCC specimens using quantitative real-time polymerase chain reaction analysis, and the correlation between the mtDNA copy number and the clinicopathologic parameters and mutations in the D-loop region of the mitochondrial genome.ResultsThe mtDNA copy number was reduced in HCCs compared with the corresponding non-cancerous liver tissues (p=0.002), and significantly correlated with tumour size (p=0.014) and cirrhosis (p=0.048). Patients with a low mtDNA copy number tended to show shorter 5-year survival rates than patients with a high mtDNA copy number when assessed by Kaplan–Meier curves, but not a significant (overall survival rate, 63 vs 83%; p=0.19). The copy number of HCC with mtDNA D-loop mutation or deletion was lower, but not significantly so (p=0.656, p=0.590, respectively).ConclusionsOur results indicated that a reduced copy number of mtDNA is correlated with HCC and associated with malignant potential.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Surgical Oncology (EJSO) - Volume 32, Issue 3, April 2006, Pages 303–307
نویسندگان
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