کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3988901 1258603 2016 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effect of methyl butyrate aroma on the survival and viability of human breast cancer cells in vitro
ترجمه فارسی عنوان
اثر عطر متیل بوتیرات بر زنده ماندن و زنده ماندن سلول های سرطانی انسان در شرایط آزمایشگاهی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی تومور شناسی
چکیده انگلیسی

BackgroundAroma can have far reaching effects on mind, body and soul. Pleasant aromas are known to have a soothing effect on the mind and are known to relieve stress and enhance concentration. Recently, it has been demonstrated that aroma may also have some curative effects as well as benefits and can be used both for prophylaxis and therapy of diseases. Our aim was to test our hypothesis whether aroma can cure or prevent cancer. Methyl butyrate (MB) is the methyl ester of butyric acid having a characteristic sweet and fruity odor like that of apples and pineapples. It occurs in many plant products in minute quantities and in pineapple oil.MethodsIn the present study, the effect of aroma of MB has been evaluated on human breast cancer cell line MDA-MB-231 in vitro. The percentage viability of the cell line was determined by using Trypan blue dye exclusion assay.ResultsIt was found that MB at a concentration of 0.01 M was effective in causing considerable cytotoxicity (40%) in breast cancer cells (without even coming in contact with cells) while at 0.02 M, % cytotoxicity was found to be 50%. Mechanism of action of MB on cancer cells was investigated by acridine orange–ethidium bromide assay using fluorescence microscopy and DNA fragmentation assay. MB aroma appeared to induce necrosis in cancer cells exposed to it.ConclusionNo study involving the effect of aroma/smell on cancer cells has ever been reported before and warrants further investigation on other cancer and normal cell lines.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the Egyptian National Cancer Institute - Volume 28, Issue 2, June 2016, Pages 81–88
نویسندگان
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