کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3990334 | 1258732 | 2012 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Maintenance Therapy and Advanced Non–Small-Cell Lung Cancer: A Skeptic's View
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
تومور شناسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Maintenance chemotherapy has a long history of use in hematologic malignancies, in which the benefits are considerable in terms of survival and quality of life. Recently, several studies have demonstrated that maintenance therapy in non–small-cell lung cancer can prolong overall survival in patients who have benefited from initial platinum-based chemotherapy. These studies have led to regulatory approval of two agents (pemetrexed and erlotinib) in this setting. We raise several issues regarding the design and execution of these studies, which question the validity of these conclusions, and explore aspects of the trial results concerning the optimal use of this approach, if it is to be accepted.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Thoracic Oncology - Volume 7, Issue 9, September 2012, Pages 1331–1336
Journal: Journal of Thoracic Oncology - Volume 7, Issue 9, September 2012, Pages 1331–1336
نویسندگان
Martin J. Edelman, Thierry Le Chevalier, Jean-Charles Soria,