Intensity modulated radiation therapy reduces gastrointestinal toxicity in locally advanced pancreas cancer

IMRT is associated with significant lower grade 2 + GI toxicity versus 3D-CRT for patients undergoing definitive chemoradiation therapy for LAPC. Because IMRT is better tolerated at higher doses and may allow further dose escalation, potentially improving local control for this aggressive disease. Further prospective studies of dose-escalated chemoradiation using IMRT are warranted.