Meta-analysis of 18FDG PET-CT for nodal staging in patients with esophageal cancer

BackgroundWe aimed to evaluate the value of 18FDG PET-CT for detection of regional nodal metastasis in patients with esophageal cancer before surgery.MethodsA computer search about PET-CT original articles was conducted from January 2000 to December 2012. The reference standard was histopathologic analysis. Two reviewers independently searched articles and extracted data. Sensitivity, specificity, diagnostic odds ratio, and likelihood ratio were pooled for PET-CT using bivariate models. Summary receiver operating characteristic (SROC) curves were also used to summarize overall test performance.ResultsAcross all seven studies on a per-station analysis (2232 stations), the pooled sensitivity and specificity with 95% confidence interval for PET-CT were 0.62 (0.40–0.79) and 0.96 (0.93–0.98). Across all 6 studies on a per-patient analysis (245 patients), corresponding values for PET-CT were 0.55 (0.34–0.74) and 0.76 (0.66–0.83).Conclusions18FDG PET-CT had lower sensitivity and accuracy for detection of regional nodal metastasis in patients with esophageal cancer before surgery.