کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4001628 1259416 2007 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The role of deoxyribonucleic acid methylation in development, diagnosis, and prognosis of bladder cancer
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی تومور شناسی
پیش نمایش صفحه اول مقاله
The role of deoxyribonucleic acid methylation in development, diagnosis, and prognosis of bladder cancer
چکیده انگلیسی

Alterations in global levels and regional patterns of deoxyribonucleic acid methylation are among the earliest and most common events known to occur in human cancer. The mutational and epigenetic effects of this covalent deoxyribonucleic acid modification to the development of bladder cancer are well recognized. The contribution of aberrant methylation to mutational hot spots located within genes, transcriptional silencing, and chromosomal instability is reviewed in the context of its relevance to bladder carcinogenesis. Understanding how such processes evolve during the progression of bladder cancer is essential for using these molecular changes in the clinical setting. The recent development of sensitive and specific techniques for quantifying methylation changes in urine specimens and bodily fluids underscores the potential use of this molecular marker for early detection and surveillance of bladder cancer. Further refinement of these molecular biological techniques holds much promise for the use of methylation markers for bladder cancer diagnosis, risk stratification, and disease prognostication.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Urologic Oncology: Seminars and Original Investigations - Volume 25, Issue 3, May–June 2007, Pages 228–235
نویسندگان
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