کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4001700 1259422 2007 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Differential expression of vascular endothelial growth factor165b in transitional cell carcinoma of the bladder
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی تومور شناسی
پیش نمایش صفحه اول مقاله
Differential expression of vascular endothelial growth factor165b in transitional cell carcinoma of the bladder
چکیده انگلیسی

Angiogenesis or the development of new blood vessels from the surrounding vasculature is essential for the growth and progression of solid tumors. Vascular endothelial growth factor (VEGF), a positive regulator of angiogenesis, plays a pivotal role in tumor angiogenesis and shows a high expression in almost all known tumors, including transitional cell carcinoma (TCC) of the bladder. A novel isoform, VEGF165b containing a novel exon 9, was recently identified in renal cell carcinoma and was shown to be down-regulated and inhibitory in nature. We aimed to analyze quantitatively expression of this isoform, VEGF165b, in TCC of the bladder and compare it to the benign part of the same organ. A real-time reverse transcriptase polymerase chain reaction protocol was set up to quantitate simultaneously the messenger ribonucleic acid levels of VEGF and VEGF165b from 34 clinical samples representing bladder cancer and matched benign tissue. Expression of VEGF165b showed a ≥3.0-fold change in 27 of 34 (79%) bladder tumors than the benign samples. Increased expression of VEGF165b was seen in superficial tumors as compared to invasive tumors, which was statistically significant (P < 0.001). Therefore, VEGF165b was up-regulated in TCC of the bladder.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Urologic Oncology: Seminars and Original Investigations - Volume 25, Issue 4, July–August 2007, Pages 317–321
نویسندگان
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