کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4130821 | 1271097 | 2007 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Histopathology and molecular pathology of intestinal metaplasia
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کلمات کلیدی
CDX2MUC5ACCDX1Muc2MUC6Lewis antigen - آنتی ژن لوئیسImmunohistochemistry - ایمونوهیستوشیمیGastric cancer - سرطان معدهStem cell - سلول بنیادیPaneth Cell - سلول پنتGoblet cell - سلول گوبلPhenotype - فنوتیپIntestinal metaplasia - متاپلازی رودهStomach - معده یا شکمMucin - موسین Helicobacter pylori - هلیکوباکتر پیلوری
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
آسیبشناسی و فناوری پزشکی
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چکیده انگلیسی
The pathogenesis of intestinal metaplasia (IM) of the human stomach remains completely unknown. Several classifications of IM have been suggested. Recent investigators have examined epithelial cell phenotypes in IM through immunohistochemistry, and revealed that gastric IM glands consist of a mixture of gastric and intestinal cell phenotypes. This implies that a heterogeneous cell population with both gastric and intestinal phenotypes would develop into a single intestinal phenotype. Recently, an intestinal stem cell marker was found to be present in the putative position of human gastric glands, whereas it was absent in gastric IM glands. This supports the assumption that IM is a consequence of abnormal stem cell differentiation, leading to lack of differentiation into any of the normal intestinal epithelial phenotypes. Recent advances in molecular biology have revealed intestinal transcriptional factors (Cdx1/Cdx2), suggesting that upregulation of Cdx2 may trigger the initiation and development of IM in the stomach. Epidemiological evidence indicates that Helicobacter pylori is a major cause of IM but might not be solely responsible for its induction. A variation in host and bacterial background that predisposes to the development of IM has been revealed.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Diagnostic Pathology - Volume 13, Issue 4, August 2007, Pages 331-339
Journal: Current Diagnostic Pathology - Volume 13, Issue 4, August 2007, Pages 331-339
نویسندگان
Y. Akasaka, T. Ishii,